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insulin, insulin resistance, diabetes care, diabetes medicine, diabetes =
medications, diabetes treatment, diabetes management, bl"=20
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height=3D58=20
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                                <P><B><FONT=20
                                face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                                size=3D-1>Medical &amp; Scientific =
Affairs=20
                                <BR></FONT></B><FONT=20
                                face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                                size=3D-1>201 Tabor Road<BR>Morris =
Plains, NJ=20
                                07950=20
                          =
</FONT></P></TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE></P>
                        <P align=3Dleft>
                        <TABLE cellSpacing=3D0 cellPadding=3D0 =
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                          <TBODY>
                          <TR>
                            <TD align=3Dmiddle><IMG id=3DRectangle3 =
height=3D61=20
                              alt=3D"IMPORTANT DRUG =
WARNING&#13;&#10;PRODUCT WITHDRAWAL"=20
                              =
src=3D"http://www.rezulin.com/assets/a_Rectangle_4.gif"=20
                              width=3D305 =
border=3D0></TD></TR></TBODY></TABLE></P>
                        <P align=3Dleft><B><FONT=20
                        face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                        size=3D-1>William R. Sigmund II, M.D.<BR>M.H.S., =

                        F.A.C.C.<BR></FONT></B><FONT=20
                        face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                        size=3D-1>Vice President</FONT></P>
                        <P align=3Dleft><B><FONT=20
                        face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                        size=3D-1>March 22, 2000</FONT></B></P>
                        <P align=3Dleft><B><FONT=20
                        face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                        size=3D-1>Dear Pharmacist:</FONT></B></P>
                        <P><FONT=20
                        face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                        size=3D-1>Following discussions with the U.S. =
Food and=20
                        Drug Administration, Warner-Lambert Company has=20
                        voluntarily discontinued the sale and =
distribution of=20
                        Rezulin<SUP>=AE</SUP> (troglitazone) Tablets, =
its therapy=20
                        for the treatment of type 2 diabetes. We have =
attached=20
                        to this letter the <A=20
                        =
href=3D"http://www.warnerlambert.com/press/release.asp?release=3D109">Com=
pany's</A>=20
                        and the <A=20
                        =
href=3D"http://www.fda.gov/bbs/topics/news/new00721.html">FDA's</A>=20
                        March 21, 2000 press releases announcing this=20
                        action.</FONT></P>
                        <P><FONT=20
                        face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                        size=3D-1>Concurrent with this letter, we are =
notifying=20
                        physicians of the withdrawal.</FONT></P>
                        <P><FONT=20
                        face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                        size=3D-1>Effective immediately, please do not =
dispense=20
                        any further prescriptions for&nbsp; =
Rezulin<SUP>=AE</SUP>.=20
                        Patients presenting prescriptions =
for</FONT><FONT=20
                        size=3D-1> </FONT><FONT=20
                        face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                        size=3D-1>Rezulin<SUP>=AE&nbsp; </SUP>should be =
instructed=20
                        to consult with their physicians regarding =
alternative=20
                        therapies as soon as possible.</FONT></P>
                        <P><FONT=20
                        face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                        size=3D-1>Warner-Lambert has discontinued its =
distribution=20
                        of Rezulin<SUP>=AE</SUP> and will be taking =
steps to=20
                        arrange for wholesale and pharmacy returns of =
all=20
                        existing stocks to the Company. Warner-Lambert =
will=20
                        reimburse patients for their out-of-pocket =
expenses for=20
                        unused supplies of Rezulin<SUP>=AE</SUP>. =
Patients having=20
                        questions regarding this procedure may call=20
                        1-877-798-7398 for instructions.</FONT></P>
                        <P><FONT=20
                        face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                        size=3D-1>You will be contacted shortly =
regarding=20
                        procedures for return of and credit for unused =
stocks.=20
                        Should you have any questions in the interim, =
please=20
                        call our Medical Affairs Department at =
1-800-223-0432 or=20
                        contact a local Parke-Davis or Sankyo Parke =
Davis=20
                        representative.</FONT></P>
                        <P><FONT=20
                        face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                        size=3D-1>Sincerely,</FONT></P>
                        <P align=3Dleft>
                        <TABLE cellSpacing=3D0 cellPadding=3D0 =
width=3D"100%" border=3D0=20
                        NOF=3D"TE">
                          <TBODY>
                          <TR>
                            <TD align=3Dleft><IMG id=3DPicture14 =
height=3D73=20
                              =
src=3D"http://www.rezulin.com/assets/sig2.gif"=20
                              width=3D273 =
border=3D0></TD></TR></TBODY></TABLE><B><FONT=20
                        face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                        size=3D-1>William R. Sigmund II, M.D.<BR>M.H.S., =

                        F.A.C.C.<BR></FONT></B><FONT=20
                        face=3D"Arial,Helvetica,Univers,Zurich =
BT,sans-serif"=20
                        size=3D-1>Vice President, Medical &amp; =
Scientific Affairs=20
                        =
</FONT></P></TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE></P></TD><=
/TR>
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name=3Dmap0><AREA=20
                    shape=3DRECT alt=3D"" coords=3D0,24,167,53=20
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</TD>
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                  width=3D77=20
    =
border=3D0></TD></TR></TBODY></TABLE></P></TD></TR></TBODY></TABLE></TD><=
/TR>
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          border=3D0></TD></TR></TBODY></TABLE><BR><FONT=20
      face=3D"Arial,Helvetica,Univers,Zurich BT,sans-serif" =
size=3D-1>The=20
      information on this site is intended for U.S. residents only. =
</FONT></P>
      <P><FONT face=3D"Arial,Helvetica,Univers,Zurich BT,sans-serif" =
size=3D-1>=A92000=20
      Parke-Davis Pharmaceuticals, Ltd. All rights reserved. Use of and =
access=20
      to the information on this site are subject to the terms and =
conditions=20
      set out in the Agreement to use the <A=20
      href=3D"http://www.warner-lambert.com/">Warner-Lambert Company</A> =
web=20
      sites. Please review the <A=20
      href=3D"http://www.warner-lambert.com/legal.html">Legal =
Agreement</A> and <A=20
      href=3D"http://www.warner-lambert.com/privacy.html">Privacy =
Statement</A>=20
      before proceeding. <BR></FONT>&nbsp;</P><PRE><FONT =
size=3D-2>&nbsp;</FONT></PRE></TD></TR></TBODY></TABLE>
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